Research output

Publications

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2026

  1. Substrate selectivity of the human RNA m(5)C methyltransferase NSUN2.

    Canepa J, Ruiz-Arroyo VM, Schlamowitz NS, Nam Y.

    Nature. 2026 Jul;655(8123):801-808. doi: 10.1038/s41586-026-10582-9. Epub 2026 May 27. PubMed PMID: 42203868; PubMed Central PMCID: PMC13289585.

  2. Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia.

    Ren L, Zhang H, Bobileva O, Nai F, Bi H, Chan A, Baker GE, Dong L, Guarin D, Hu W, Li W, Leite I, Wang X, Zhang X, Xue M, Wang H, Qin H, Wu X, Ghoda L, Xu L, Zhang B, Li L, Wunderlich M, Mulloy JC, Jones CL, O'Leary SE, Li H, Rosen ST, Chen CD, Heisterkamp N, Perry JJP, Nam Y, Chen J, Caflisch A, Li X, Su R.

    Blood. 2026 Jun 18;147(25):3069-3085. doi: 10.1182/blood.2025030336. PubMed PMID: 42247311.

2024

  1. Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

    Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y.

    Sci Adv. 2024 Dec 20;10(51):eads4750. doi: 10.1126/sciadv.ads4750. Epub 2024 Dec 20. PubMed PMID: 39705353; PubMed Central PMCID: PMC11661435.

  2. Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8.

    Khadgi B, Nam Y.

    bioRxiv. 2024 Oct 17;. doi: 10.1101/2024.10.15.618347. PubMed PMID: 39464105; PubMed Central PMCID: PMC11507685.

  3. U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs.

    Shen A, Hencel K, Parker MT, Scott R, Skukan R, Adesina AS, Metheringham CL, Miska EA, Nam Y, Haerty W, Simpson GG, Akay A.

    Nucleic Acids Res. 2024 May 29;. doi: 10.1093/nar/gkae447. PubMed PMID: 38808663.

  4. Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.

    Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q.

    J Clin Invest. 2024 Apr 15;134(8). doi: 10.1172/JCI175703. PubMed PMID: 38618952; PubMed Central PMCID: PMC11014668.

2023

  1. Structures and mechanisms of tRNA methylation by METTL1-WDR4.

    Ruiz-Arroyo VM, Raj R, Babu K, Onolbaatar O, Roberts PH, Nam Y.

    Nature. 2023 Jan;613(7943):383-390. doi: 10.1038/s41586-022-05565-5. Epub 2023 Jan 4. PubMed PMID: 36599982; PubMed Central PMCID: PMC9930641.

2022

  1. Dynamic Protein-RNA recognition in primary MicroRNA processing.

    Ruiz-Arroyo VM, Nam Y.

    Curr Opin Struct Biol. 2022 Oct;76:102442. doi: 10.1016/j.sbi.2022.102442. Epub 2022 Sep 5. Review. PubMed PMID: 36067707; PubMed Central PMCID: PMC9509664.

  2. METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis.

    Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J.

    Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. PubMed PMID: 35145225; PubMed Central PMCID: PMC9070413.

2020

  1. Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.

    Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, Nam Y.

    Mol Cell. 2020 May 7;78(3):411-422.e4. doi: 10.1016/j.molcel.2020.02.016. Epub 2020 Mar 27. PubMed PMID: 32220646; PubMed Central PMCID: PMC7214211.

2019

  1. RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.

    Ngo TD, Partin AC, Nam Y.

    Cell Rep. 2019 Dec 17;29(12):4024-4035.e5. doi: 10.1016/j.celrep.2019.11.059. PubMed PMID: 31851931; PubMed Central PMCID: PMC6953907.

  2. Manipulation by Methylation: Garnishing mRNAs with m(6)Am.

    Doxtader KA, Nam Y.

    Mol Cell. 2019 Aug 8;75(3):417-418. doi: 10.1016/j.molcel.2019.07.019. PubMed PMID: 31398320; PubMed Central PMCID: PMC6860360.

2018

  1. Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.

    Doxtader KA, Wang P, Scarborough AM, Seo D, Conrad NK, Nam Y.

    Mol Cell. 2018 Sep 20;71(6):1001-1011.e4. doi: 10.1016/j.molcel.2018.07.025. Epub 2018 Sep 6. PubMed PMID: 30197297; PubMed Central PMCID: PMC6367934.

  2. Publisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.

    Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y.

    Nat Commun. 2018 Sep 18;9(1):3852. doi: 10.1038/s41467-018-06426-4. PubMed PMID: 30228298; PubMed Central PMCID: PMC6143526.

  3. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.

    Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P.

    Cell Rep. 2018 Jun 5;23(10):3091-3101. doi: 10.1016/j.celrep.2018.04.116. PubMed PMID: 29874593; PubMed Central PMCID: PMC6511231

2017

  1. Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.

    Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y.

    Nat Commun. 2017 Nov 23;8(1):1737. doi: 10.1038/s41467-017-01713-y. PubMed PMID: 29170488; PubMed Central PMCID: PMC5700927.

  2. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.

    Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P.

    Cell Rep. 2017 Mar 14;18(11):2664-2675. doi: 10.1016/j.celrep.2017.02.044. PubMed PMID: 28297670; NIHMSID:NIHMS857583.

2016

  1. HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.

    Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, Liu Q.

    Mol Cell. 2016 Aug 4;63(3):420-32. doi: 10.1016/j.molcel.2016.06.014. Epub 2016 Jul 14. PubMed PMID: 27425409; PubMed Central PMCID: PMC4975613.

  2. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

    Wang P, Doxtader KA, Nam Y.

    Mol Cell. 2016 Jul 21;63(2):306-317. doi: 10.1016/j.molcel.2016.05.041. Epub 2016 Jun 30. PubMed PMID: 27373337; PubMed Central PMCID: PMC4958592.

  3. Data publication with the structural biology data grid supports live analysis.

    Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

    Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882. PubMed PMID: 26947396; PubMed Central PMCID: PMC4786681.

2012

  1. A grid-enabled web service for low-resolution crystal structure refinement.

    O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P.

    Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):261-7. doi: 10.1107/S0907444912001163. Epub 2012 Feb 14. PubMed PMID: 22349228; PubMed Central PMCID: PMC3282622.

  2. Conformational locking upon cooperative assembly of notch transcription complexes.

    Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.

    Structure. 2012 Feb 8;20(2):340-9. doi: 10.1016/j.str.2011.12.011. PubMed PMID: 22325781; PubMed Central PMCID: PMC3285698.

2011

  1. Molecular basis for interaction of let-7 microRNAs with Lin28.

    Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P.

    Cell. 2011 Nov 23;147(5):1080-91. doi: 10.1016/j.cell.2011.10.020. Epub 2011 Nov 10. PubMed PMID: 22078496; PubMed Central PMCID: PMC3277843.

  2. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

    Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS.

    PLoS One. 2011;6(10):e25645. doi: 10.1371/journal.pone.0025645. Epub 2011 Oct 13. PubMed PMID: 22022427; PubMed Central PMCID: PMC3192765.

  3. Structure of human O-GlcNAc transferase and its complex with a peptide substrate.

    Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S.

    Nature. 2011 Jan 27;469(7331):564-7. doi: 10.1038/nature09638. Epub 2011 Jan 16. PubMed PMID: 21240259; PubMed Central PMCID: PMC3064491.

2008

  1. Structure of a complex of the ATPase SecA and the protein-translocation channel.

    Zimmer J, Nam Y, Rapoport TA.

    Nature. 2008 Oct 16;455(7215):936-43. doi: 10.1038/nature07335. PubMed PMID: 18923516; PubMed Central PMCID: PMC7164768.

  2. A role for the two-helix finger of the SecA ATPase in protein translocation.

    Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA.

    Nature. 2008 Oct 16;455(7215):984-7. doi: 10.1038/nature07439. PubMed PMID: 18923526; PubMed Central PMCID: PMC4354775.

2007

  1. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

    Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC.

    Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2103-8. doi: 10.1073/pnas.0611092104. Epub 2007 Feb 6. PubMed PMID: 17284587; PubMed Central PMCID: PMC1892977.

2006

  1. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

    Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC.

    Mol Cell Biol. 2006 Aug;26(16):6261-71. doi: 10.1128/MCB.02478-05. PubMed PMID: 16880534; PubMed Central PMCID: PMC1592797.

  2. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

    Nam Y, Sliz P, Song L, Aster JC, Blacklow SC.

    Cell. 2006 Mar 10;124(5):973-83. doi: 10.1016/j.cell.2005.12.037. PubMed PMID: 16530044; NIHMSID:NIHMS154980.

2003

  1. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.

    Nam Y, Weng AP, Aster JC, Blacklow SC.

    J Biol Chem. 2003 Jun 6;278(23):21232-9. doi: 10.1074/jbc.M301567200. Epub 2003 Mar 18. PubMed PMID: 12644465.

  2. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

    Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.

    Mol Cell Biol. 2003 Jan;23(2):655-64. doi: 10.1128/MCB.23.2.655-664.2003. PubMed PMID: 12509463; PubMed Central PMCID: PMC151540.

2002

  1. Notch signaling as a therapeutic target.

    Nam Y, Aster JC, Blacklow SC.

    Curr Opin Chem Biol. 2002 Aug;6(4):501-9. doi: 10.1016/s1367-5931(02)00346-0. Review. PubMed PMID: 12133727.